1991 İSTANBUL ÜNİVERSİTESİ İSTANBUL TIP FAKÜLTESİ
1991-1995: İSTANBUL ÜNİVERSİTESİ İSTANBUL TIP FAKÜLTESİ KULAK BURUN BOĞAZ-BAŞ&BOYUN CERRAHİSİ Uzmanlık Eğitimi
1997 Clinical Fellowship: Marburg University, Fulda Teaching Hospital,ENT-Head&Neck and Facial Plastic Surgery.Fulda,Germany
2002 Doçent Doktor KBB Hastalıkları. İÜ.İstanbul Tıp Fak.KBB Hast.AD
2004 Clinical Fellowship: Virginia University, ORL-H&N Department,Facial Plastic and Reconstructive Surgery. International Fellowship, USA
2004 Oregon Health&Science University, ORL-H&N Department,Facial Plastic and Reconstructive Surgery. International Fellowship, USA
2007 Profesör Doktor KBB Hastalıkları. İÜ.İstanbul Tıp Fak.KBB Hast.AD
1991-Halen İSTANBUL ÜNİVERSİTESİ İSTANBUL TIP FAKÜLTESİ-KBB HASTALIKLARI ANABİLİM DALI
2008-Halen Muayenehane Serbest Hekimlik
Türk KBB ve Baş Boyun Cerrahisi Derneği
Türk Kulak Burun Boğaz ve Baş Boyun Cerrahisi Vakfı
Türk Larengoloji Derneği
Avrupa Rinoloji Derneği
Yüz Plastik Cerrahi Deneği (Kurucu Üye, Yönetim Kurulu Başkanı)
Avrupa Fasiyal Plastik Cerrahi Akademisi
Copy number profiling of tumor suppressor genes in head and neck cancer.
Yalniz Z, Demokan S, Karabulut B, Ulusan M, Suoglu Y, Dalay N.
Head Neck. 2017 Feb;39(2):341-346. doi: 10.1002/hed.24593. Epub 2016 Oct 3.
Prevalence of allergic fungal rhinosinusitis among patients with chronic rhinosinusitis with or without nasal polyposis who underwent endonasal sinus surgery in northwestern Turkey.
Demir D, Süoğlu Y, Güven M, Yılmaz MS.
Kulak Burun Bogaz Ihtis Derg. 2014 Sep-Oct;24(5):259-64. doi: 10.5606/kbbihtisas.2014.24382.
Is it necessary to remove submandibular glands in squamous cell carcinomas of the oral cavity?
Basaran B, Ulusan M, Orhan KS, Gunes S, Suoglu Y.
Acta Otorhinolaryngol Ital. 2013 Apr;33(2):88-92.
The impact of social and demographic features on comprehensive receptive and expressive performance in cochlear implant patients.
Polat B, Başaran B, Kara HC, Ataş A, Süoğlu Y.
Kulak Burun Bogaz Ihtis Derg. 2013 Mar-Apr;23(2):90-5. doi: 10.5606/kbbihtisas.2013.04378.
1- Surgery in cochlear implantation Orhan KS, Celik M, Başaran B, Ulusan M, Comoğlu S, Karabulut B, Süoğlu Y, Güldiken Y, Değer K. Kulak Burun Bogaz Ihtis Derg. 2012 Nov-Dec;22(6):311-8. doi: 10.5606/kbbihtisas.2012.060. Turkish. PMID: 23176694 [PubMed - in process]
2- Radiation-induced osteosarcoma of the larynx:a case report and literature review. Ulusan M, Yilmazer R, Ozluk Y, Enoz M, Suoglu Y. Ear Nose Throat J. 2012 Oct;91(10):E22-5. PMID: 23076859 [PubMed - in process]
3- The use of botulinum toxin type A in masseteric muscle hypertrophy: long-term effects and lasting improvement Aydil B, Başaran B, Unsaler S, Süoğlu Y. Kulak Burun Bogaz Ihtis Derg. 2012 Sep-Oct;22(5):249-53. doi: 10.5606/kbbihtisas.2012.049. Turkish. PMID: 22991984 [PubMed - in process]
4- Promoter methylation and loss of p16(INK4a) gene expression in head and neck cancer Demokan S, Chuang A, Suoğlu Y, Ulusan M, Yalnız Z, Califano JA, Dalay N. Head Neck. 2012 Oct;34(10):1470-5. doi: 10.1002/hed.21949. Epub 2011 Nov 22. PMID: 22106032 [PubMed - in process]
5- Yalniz, Z ; Demokan, S; Suoglu, Y ; Ulusan, M ; Dalay, N Title: Simultaneous Methylation Profiling of Tumor Suppressor Genes in Head and Neck Cancer Source: DNA AND CELL BIOLOGY, 30 (1): 17-24 JAN 2011 Abstract: Head and neck cancer (HNC) is a common cancer, and its prognosis has not changed during the last decades. Detection of the disease at an early stage is crucial for successful treatment, as early diagnosis can significantly increase the survival rate. Methylation of tumor suppressor genes is an early event in cancer responsible for incorrect gene silencing. Since methylation changes are reversible, they also provide a promising target for therapy. So far, only individual genes have been analyzed for aberrant methylation in HNC. In this study, we analyzed the methylation status of 24 tumor suppressor genes simultaneously by methylation-specific multiplex ligation-dependent probe amplification in matched tumor and normal tissue samples from patients with HNC. CHFR, RAR beta, DAPK1, and RASFF1 genes were the most frequently methylated genes in tumor tissue. Eight genes were not methylated in any sample. The methylation frequencies for individual genes ranged from 0% to 19%. Our results indicate that methylation of tumor suppressor genes is not high as previously reported by methylation-specific polymerase chain reaction and is confined to a smaller but significant fraction of the tumors. Whether this group represents a unique entity in the disease spectrum warrants further studies. ISSN: 1044-5498 DOI: 10.1089/dna.2010.1090
6- Ulusan M, Enöz M, Kumral TL, Süoğlu Y. The effect of tumor width and depth on extracapsular lymp node metastases in tongue tumors., Kulak Burun Bogaz Ihtis Derg. 2010 Jan-Feb;20(1):18-24
7- Demokan, S (Demokan, Semra); Suoglu, Y (Suoglu, Yusufhan); Gozeler, M (Gozeler, Mustafa); Demir, D (Demir, Deniz); Dalay, N (Dalay, Nejat) Title: N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer Source: MOLECULAR BIOLOGY REPORTS, 37 (7): 3217-3226 OCT 2010 Abstract: Polymorphisms that alter the function of genes involved in the activation or detoxification of carcinogenic compounds can influence an individuals risk of developing cancer. Polymorphic changes modulating the acetylation capacity of the N-acetyltransferase (NAT) genes have been implicated in the risk of developing cancer. In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated. Polymorphic regions of the NAT1 and NAT2 genes were analyzed in patients with head and neck cancer and healthy individuals by polymerase chain reaction-restriction fragment length polymorphism. Distribution of the genotypes, allele frequencies, diplotypes and haplotypes and correlation with clinical characteristics were evaluated. No association was observed between the NAT1*3, NAT1*10, NAT1*11, NAT2*5 and NAT2*6 genotypes and risk of head and neck cancer. The NAT2*7 slow genotype was associated with reduced risk of disease. A significant association was observed between the fast acetylator NAT2*4/NAT1*10 diplotype and risk of head and neck cancer. Combined haplotypes harboring the T1088A and C1095A variants characterizing the NAT1*10 allele were associated with increased risk. Our results suggest that NAT1 and NAT2 gene combinations may influence the risk of developing head and neck cancer. ISSN: 0301-4851 DOI: 10.1007/s11033-009-9905-8
8- Yalniz, Z (Yalniz, Zubeyde); Demokan, S (Demokan, Semra); Suoglu, Y (Suoglu, Yusufhan); Ulusan, M (Ulusan, Murat); Dalay, N (Dalay, Nejat) Title: Assessment of microsatellite instability in head and neck cancer using consensus markers Source: MOLECULAR BIOLOGY REPORTS, 37 (7): 3541-3545 OCT 2010 Abstract: Head and neck cancer is the sixth most common cancer in the world and one of the most lethal cancers. Microsatellite instability is an important characteristic of tumor cells and is observed both in presence and absence of http://pcs.isiknowledge.com/uml/uml_view.cgi?product_sid=Z1eJGco...&print_opt=Field+Tagged&print_output.x=1&SID=Z1eJGco6ppb7kbOeP5b Page 1 of 9 Format for Print Page 3/28/11 11:59 AM mismatch repair gene mutations. The importance of microsatellite instability in head and neck cancer is not well established due to the lack of a consensus panel and selection of different markers, criteria and methodological variances. The main objective of this study was to investigate the performance of a consensus panel of microsatellite repeats by automated fragment analysis. Matched tumor and normal tissue samples from 99 patients were analyzed using five mononucleotide markers. Following PCR the amplified fragments were analyzed by capillary electrophoresis on an ABI 310 genetic analyzer. Microsatellite instability was observed in 26 patients. In 17 patients instability was detected at multiple loci. NR21 and BAT25 were the most frequently altered targets. These two mononucleotide markers could detect all samples displaying high-instability. In this study we describe a standardized fluorescent multiplex PCR combined with computerized analysis, which allows rapid and accurate analysis of a high number of samples and obviates the need to compare tumors with matching normal tissue. ISSN: 0301-4851 DOI: 10.1007/s11033-010-0001-
9- Demokan, S (Demokan, Semra); Suoglu, Y (Suoglu, Yusufhan); Ulusan, M (Ulusan, Murat); Dalay, N (Dalay, Nejat) Title: Analysis of the hMSH2 Gene Variants in Head and Neck Cancer Source: DNA AND CELL BIOLOGY, 29 (8): 449-457 AUG 2010 Abstract: The hMSH2 (human MutS homolog 2) gene plays a central role in DNA mismatch repair. Structural variations in the gene may lead to protein instability and deficient mismatch repair. However, the role of polymorphic variants of the hMSH2 gene have not been defined in head and neck cancer. In this study, the roles of three polymorphic variants in the functional domains of the gene were investigated in 166 patients with head and neck cancer by allele-specific PCR, electronical array addressing, and PCR/RFLP (restriction fragment length polymorphism). This is the first study to investigate the gIVS12-6T -> C polymorphism in head and neck cancer. A significant association between the CC genotype and reduced risk of disease suggests that the gIVS12-6T -> C substitution at the splice-acceptor site may affect the risk of head and neck cancer. We did not observe an association between the Asn127Ser and Gly322Asp polymorphisms and cancer risk. A possible role of the gIVS12-6T -> C substitution warrants further validation in larger cohorts because of low allele frequency. ISSN: 1044-5498 DOI: 10.1089/dna.2009.1013
10- Gozeler, M (Gozeler, M.); Suoglu, Y (Suoglu, Y.); Enoz, M (Enoz, M.); Colhan, I (Colhan, I.); Demiryont, M (Demiryont, M.) Title: Myofibroma of the external auditory canal: report of an adult case Source: B-ENT, 5 (4): 273-275 2009 Abstract: Myofibroma of the external auditory canal: report of an adult case. Objective: Myofibroma is a benign fibrous proliferative disease generally reported to occur in neonates and children. Similar lesions have been reported in adults, but solitary tumours affecting the external auditory canal are extremely rare. Only one such case has been reported in the literature. Case report: The case of solitary myofibroma occurring in the external auditory canal of a 42-year-old woman is presented. The diagnosis of myofibromatosis was made on the basis of its histological appearance and corroborated by immunohistochemical staining. Conclusions: Clinicians and pathologists must be aware that myofibromatosis may occur in adults at extremely rare locations. Myofibroma should be included in the differential diagnosis of fibrous lesions in the external auditory canal. ISSN: 0001-6497
11- Dalay, N.; Yalniz, Z; Demokan, S; Demir, D; Gozeler, M; Suoglu, Y Title: Methylation of the DAPK, HIN-1 and FHIT genes in head and neck cancer Source: EJC SUPPLEMENTS, 6 (9): 150-150 JUL 2008 Conference Title: 20th Meeting of the European-Association-for-Cancer-Research Conference Date: JUL 05-08, 2008 Conference Location: Lyon, FRANCE ISSN: 1359-6349
12- Suoglu, Y (Suoglu, Y.); Guven, M (Guven, M.); Kiyak, E (Kiyak, E.); Enoz, M (Enoz, M.) Title: Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy Source: JOURNAL OF LARYNGOLOGY AND OTOLOGY, 122 (6): 623-627 JUN 2008 Abstract: Cancerous involvement of the pre-epiglottic space has been known for many years to be an important prognostic factor. The aim of this study was to investigate the prognostic value of pre-epiglottic space invasion, according to the degree of invasion (i.e. absence, minimal or gross), and to assess the oncological suitability for supracricoid partial laryngectomy in patients with supraglottic laryngeal carcinomas. This study included 52 patients with squamous cell carcinomas of the supraglottic and glotto-supraglottic larynx, treated with supracricoid partial laryngectomy-cricohyoidopexy, between 1992 and 2001. Clinical and histopathological parameters were evaluated. Pre- epiglottic space invasion was seen in 35 patients (67.3 per cent); there was gross invasion in seven patients and minimal invasion in 28. Neoplastic invasion of the anterior commissure was seen in 18 patients (34.6 per cent) and thyroid cartilage involvement in eight (15.4 per cent). Neoplastic spread through the extralaryngeal tissues was not seen in any patient. The five-year overall survival was 71.5 per cent for patients with gross pre-epiglottic space invasion, 82.2 per cent for those with minimal pre-epiglottic space invasion, and 76.4 per cent for those without pre-epiglottic space invasion. It was observed that gross or minimal pre-epiglottic space invasion did not have a statistically significant effect on survival. Univariate analysis showed that nodal positivity was associated with a poor prognosis. None of the other parameters analysed showed a statistically significant relationship with survival. Four (7.6 per cent) patients had local laryngeal recurrence. Distant metastasis and a second primary tumour were detected in three (5.8 per cent) and four (7.6 per cent) patients, respectively. The five-year overall survival and cause-specific survival were 78.8 and 82 per cent, respectively. Supracricoid partial laryngectomy with cricohyoidopexy can safely be performed in supraglottic and glotto-supraglottic carcinomas with minimal or gross invasion of the pre-epiglottic space which have no extralaryngeal spread. Nodal status is an important predictor affecting survival. ISSN: 0022-2151 DOI: 10.1017/S0022215107000370
13- Aydin, K (Aydin, Kubilay); Terzibasioglu, E (Terzibasioglu, Ege); Sencer, S (Sencer, Serra); Sencer, A (Sencer, Altay); Suoglu, Y (Suoglu, Yusufhan); Karasu, A (Karasu, Aykut); Kiris, T (Kiris, Talat); Turantan, MI (Turantan, M. Inan) Title: Localization of cerebrospinal fluid leaks by gadolinium-enhanced magnetic resonance cisternography: A 5-year single-center experience Source: NEUROSURGERY, 62 (3): 584-589 MAR 2008 Abstract: OBJECTIVE: Intrathecal gadolinium (Gd)-enhanced magnetic resonance (MR) cisternography is a newly introduced imaging method. Two main objectives of this study were to investigate the sensitivity of Gd-enhanced MR cisternography for presurgical localization of cerebrospinal fluid (CSF) leaks in patients with CSF rhinorrhea and to study the potential long-term adverse effects of intrathecal Gd application. METHODS: Fifty-one patients (19 women; mean age, 36.2 yr) with CSF rhinorrhea were included in the study. A total of 0.5 ml of Gd was injected into the lumbar subarachnoid space. T1-weighted MR cisternographic images were obtained to detect CSF leakage. The patient's neurological states and vital signs were recorded for the first 24 hours after the procedure. Neurological evaluations were repeated 1, 3, and 12 months after the procedure. The patients were followed for at least 3 years with annual neurological examinations. RESULTS: Gd-enhanced MR cisternography demonstrated CSF leaks in 43 of the 51 patients. The sensitivity of Gd- enhanced MR cisternography for localization of CSF leaks was 84%. Forty-four patients underwent surgery to repair dural tears. Surgical findings confirmed the results of Gd-enhanced cisternography in 43 of the 44 patients who underwent surgery (98%). Eight patients with negative Gd-enhanced MR cisternography had no active rhinorrhea at the time of fprocedure, and seven of them did not need surgery. None of the patients developed an acute adverse reaction http://pcs.isiknowledge.com/uml/uml_view.cgi?product_sid=Z1eJGco...&print_opt=Field+Tagged&print_output.x=1&SID=Z1eJGco6ppb7kbOeP5b Page 3 of 9 Format for Print Page 3/28/11 11:59 AM that could be attributed to the procedure. None of the patients developed any neurological symptoms or signs caused by intrathecal Gd injection during a mean follow-up period of 4.12 years. CONCLUSION: Gd-enhanced MR cisternography is a sensitive and safe imaging method for detection of CSF leaks in patients with rhinorrhea. ISSN: 0148-396X DOI: 10.1227/01.NEU.0000297109.49755.2/
15- Bayrak, Y (Bayrak, Y.); Tanju, S (Tanju, S.); Suoglu, Y (Suoglu, Y.); Toker, A (Toker, A.) Title: Treatment of a benign tracheoesophageal fistula in a ventilator dependent quadriplegic patient Source: THORACIC AND CARDIOVASCULAR SURGEON, 54 (8): 554-555 DEC 2006 Abstract: Management of an acquired benign tracheoesophageal fistula in a patient who is dependent on mechanical ventilation is controversial, since the usual procedure is weaning before repair. Here, we describe surgical treatment of a tracheoesophageal fistula in a quadriplegic patient with 28 months of follow-up, who has to remain permanently on mechanical ventilation with a tracheostomy cannula. ISSN: 0171-6425 DOI: 10.1055/s-2006-914094
16- Suoglu Y, Guven M, Kiyak E, Enoz M., Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy., J Laryngol Otol. 2008 Jun;122(6):623-7. Epub 2007 Sep 21. PMID: 17888196 [PubMed - in process]
17- Enoz M, Suoglu Y, Ilhan R., Lingual schwannoma, J Cancer Res Ther. 2006 Apr-Jun;2(2):76-8. PMID: 17998681 [PubMed - indexed for MEDLINE]
18- Demokan, S (Demokan, S.); Suoglu, Y (Suoglu, Y.); Ulusan, M (Ulusan, M.); Dalay, N (Dalay, N.) Title: Promoter methylation and the gIVS12-6T/C polymorphism of the hMSH2 gene in head and neck cancer Source: FEBS JOURNAL, 273: 190-190 PP422 Suppl. 1 JUN 2006 Conference Title: 31st Congress of the Federation-of-European-Biochemical-Societies (FEBS) Conference Date: JUN 24-29, 2006 Conference Location: Istanbul, TURKEY ISSN: 1742-464X
19- Demir, D; Katircioglu, S; Suoglu, Y; Bilgic, B Title: Radiation-induced liposarcoma of the retropharyngeal space Source: OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 134 (6): 1060-1062 JUN 2006 ISSN: 0194-5998 DOI: 10.1016/j.otohns.2005.03.043
20- Enoz, M; Suoglu, Y Title: Salivary gland choristoma of the middle ear Source: LARYNGOSCOPE, 116 (6): 1033-1034 JUN 2006 Abstract: Choristoma is a mass of tissue histologically normal for an organ or part of the body other than the site at which it is located. A rare case of ectopic salivary gland choristoma in the middle ear is described in a 14-year-old girl whose only symptom was a 55 dB conductive hearing loss. The left middle ear mass appeared whitish and was located behind the intact tympanic membrane. We first suspected it to be congenital middle ear cholesteatoma. Exploratory tympanotomy, however, revealed a salivary gland choristoma that adhered tightly to the facial nerve. Differential diagnosis and treatment of this rare condition are discussed. ISSN: 0023-852X DOI: 10.1097/01.mlg.0000217250.08455.d3
21- Demokan, S; Suoglu, Y; Demir, D; Gozeler, M; Dalay, N Title: Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer Source: ANNALS OF ONCOLOGY, 17 (6): 995-999 JUN 2006 Abstract: Background: Methylation in the promoter region of the DNA mismatch repair genes hMLH1 and hMSH2 and microsatellite instability at three loci were analyzed in the tumor tissue from patients with head and neck cancer. Methods: Microsatellite instability and promoter methylation were investigated by PCR, denaturing-polyacrylamide gel electrophoresis and digestion with methylation-specific restriction enzymes. Results: Microsatellite instability was observed in 41% of the patients. hMLH1 and hMSH2 genes were methylated in 47% and 30% of the patients, respectively. BAT25 and BAT26 instability were associated with age and histopathology, respectively. Methylation frequency of the hMLH1 gene promoter was significantly higher in patients displaying a high level of microsatellite instability. Instability at the BAT 26 and D2S123 loci were associated with the MSI-high status. Conclusions: Our results indicate that microsatellite instability and modifications in the hMLH1 and hMSH2 genes are implicated in a significant proportion of the patients with head and neck cancer. ISSN: 0923-7534 DOI: 10.1093/annonc/mdl048
22- Guven, M; Suoglu, Y; Kiyak, E; Demir, D Title: Autologous fat augmentation for voice and swallow improvement after cordectomy Source: ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 68 (3): 164- 169 2006 Abstract: Surgery for the treatment of early-stage glottic carcinoma still remains a valid option. In most patients, newly formed neocord tissue preserves glottic functions, but in some patients an important glottic gap leading to glottic insufficiency may occur. In our study, 11 patients who had serious glottic insufficiency after endoscopic laser and laryngofissure cordectomy were treated with autologous fat injection (AFI) into the neocord tissue for voice and swallowing rehabilitation. One patient did not attend the first control visit and was excluded from the study. The remaining 10 patients were evaluated in the preoperative and postoperative periods for phonatory functions and efficacy of AFI by videolaryngostroboscopy and computerized acoustic analysis. Phonatory functions showed statistically significant improvement in the shimmer, noise-to-harmonic ratio, maximum phonation time and fundamental frequency. Perceptual ratings (GRBAS scale) also showed statistically significant improvement in all 5 parameters. Despite improvement in glottic closure, the mucosal wave deteriorated. Due to recurrence of symptoms of glottic insufficiency, AFI was repeated in 2 patients at the third and fifth months, respectively. One year later, the AFI resulted in successful rehabilitation of swallowing in all patients. The probability of resorption of autologous fat and the deterioration of the mucosal wave after AFI remain a problem, but re-injection can be done easily. As AFI is an easy, safe and cheap method, we concluded that it is a promising alternative procedure for managing voice problems after laser or laryngofissure cordectomy defects. Copyright (c) 2006 S. Karger AG, Basel.
23- Güven M, Süoğlu Y, Demir D, Emin H, Sunay T., Transoral microlaryngoscopic approach for schwannoma of the larynx., Kulak Burun Bogaz Ihtis Derg. 2005;15(5-6):121-4. PMID: 16444093 [PubMed - indexed for MEDLINE]
24- Demir D, Süoğlu Y, Güven M, Kapran Y., Simultaneous existence of papillary carcinoma in the thyroid gland and thyroglossal duct cyst in two patients. Kulak Burun Bogaz Ihtis Derg. 2005;15(3-4):78-82. PMID: 16340297 [PubMed - indexed for MEDLINE]
25- Güven M, Demir D, Süoğlu Y, Emin H, Kiyak E, Enöz M., [Long-term results of intracordal or neocordal autologous fat injection in patients with unilateral vocal cord paralysis and cordectomy] Kulak Burun Bogaz Ihtis Derg. 2005;15(1-2):22-9. Turkish. PMID: 16340288 [PubMed - indexed for MEDLINE]
26- Demokan, S; Demir, D; Suoglu, Y; Kiyak, E; Akar, U; Dalay, N Title: Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer Source: PATHOLOGY & ONCOLOGY RESEARCH, 11 (1): 22-25 2005 Abstract: Inherited polymorphisms in the genes controlling the cell cycle or functioning in the DNA repair mechanisms may impair their function and contribute to genetic susceptibility. Abnormalities in the DNA repair have been reported in head and neck cancer. The XRCC1 gene functions in single-strand break and base excision repair processes. In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399Gln were investigated in 95 patients with head and neck carcinoma. The polymorphic regions were amplified by PCR followed by digestion with methylation-specific restriction enzymes, and analyzed electrophoretically. Genotype and allele frequencies were calculated, and association with cancer risk or clinical parameters was investigated. No association was observed between the genotypes and head and neck cancer for either polymorphism. Distribution of the alleles did not significantly differ between the patients and the control group. A significant association was only found for the Trp194 http://pcs.isiknowledge.com/uml/uml_view.cgi?product_sid=Z1eJGco...&print_opt=Field+Tagged&print_output.x=1&SID=Z1eJGco6ppb7kbOeP5b Page 5 of 9 Format for Print Page 3/28/11 11:59 AM allele among the smoking individuals. Our data indicate that the Arg194Trp and Arg399Gln polymorphisms do not confer a significant risk for head and neck carcinogenesis. ISSN: 1219-4956
27- Demir D, Süoğlu Y, Emin H, Güven M, Kiyak E., [Factors that affect in situ lifetime of Provox voice prosthesis], Kulak Burun Bogaz Ihtis Derg. 2004;13(5-6):126-31. Turkish. PMID: 16055997 [PubMed - indexed for MEDLINE]
28- Güven M, Süoğlu Y, Erdamar B, Cölhan I, Demir D., [Orbital complications of acute sinusitis],Kulak Burun Bogaz Ihtis Derg. 2004;12(5-6):115-9. Turkish. PMID: 16020986 [PubMed - indexed for MEDLINE]
29- Emin, AH; Suoglu, Y; Demir, D; Karatay, MC Title: Normocalcemic hyperparathyroidism presented with mandibular brown tumor: Report of a case Source: AURIS NASUS LARYNX, 31 (3): 299-304 SEP 2004 Abstract: Brown tumor is a rare clinical entity complicating hyperparathyroidism. It may occur in the head and neck, with the mandible being the most frequent site. Hyperparathyroidism is usually associated with hypercalcemia. We report a case of madibular Brown tumor secondary to primary hyperparathyroidism. In this case in spite of hyperparathyroidism and the bony lesion the serum calcium level was within normal range. The case managed by surgical excision of the mandibular tumor with an en-bloc hemithyroidectomy with inclusion of the diseased parathyroid gland. This case demonstrates that in osteolytic bony lesions a hyperparathyroid complication can be expected even with normal serum calcium level. The presence of normocalcemia in primary hyperparathyroidism should prompt the physician to look for vitamin D deficiency. (C) 2004 Elsevier Ireland Ltd. All rights reserved. ISSN: 0385-8146 DOI: 10.1016/j.ant.2004.03.014
30- Oguz, F; Unuvar, E; Suoglu, Y; Erdamar, B; Dundar, G; Katircioglu, S; Sidal, M Title: Etiology of acute otitis media in childhood and evaluation of two different protocols of antibiotic therapy: 10 days cefaclor vs. 3 days azitromycin Source: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 67 (1): 43-51 JAN 2003 Abstract: Backgrounds: Acute otitis media (AOM) is a common childhood infection that is frequently treated by antibiotics. There are no prospective and comprehensive trials evaluating childhood AOM for etiologic pathogens and resistance pattern in Turkey. The aims of the study were to determine the bacterial etiologies and resistance patterns, and identify the efficacy and the relapse rates of 3 days of azitromycin and 10 days of cefaclor therapy in AOM. Methods: This prospective, randomized, single-blind, open study was carried out in 78 cases of AOM. Mean age was 30.7 +/- 27 months. Tympanocentesis and aspiration of middle ear fluid (MEF) were used to obtain purulent material from the middle ear. Group 1 consisted of the cases (n = 41) on azitromycin therapy and Group 2 (n = 37) on cefaclor. Dosage of azitromycin was 10 mg/kg per day for 3 days and cefaclor 40 mg/kg per day for 10 days. The patients were evaluated on days 3-5 (second visit), day 10 (third visit), and day 30 (fourth visit) during follow-up. Results: A total of 50 species were isolated from 44 of 78 cases from which materials were obtained (44/78; 56.4%). Most frequently isolated microorganism was Streptococcus pneumoniae (n = 18; 36%), followed by Haemophilus influenzae (n = 11; 22%), S. aureus (n = 9; 18%), Moraxella catarrhalis (n = 4; 8%), and group A beta-hemolytic streptococcus (GAS, n = 4; 8%). Enterococcus faecalis was isolated from three cases and H. parainfluenzae from one. Penicillin and amoxicillin resistances of bacteria were found to be 40 and 36%, respectively. The frequency of penicillin and amoxicillin resistance in less than or equal to24-month age group was 59 and 66.6%, respectively. The patients did not demonstrate significant differences in terms of cure rate on the third to fifth day (Group 1: 32.5%; Group 2: 36.4%), 10th day (Group 1: 76.9%; Group 2: 84.8%), and on 30th day (Group 1: 91.3%; Group 2: 81.8%). There were no significant differences with respect to side effects, relapse, and re-infection rate between the two groups. Conclusion: In more than half of the AOM cases, bacteria were isolated from MEF and most frequently isolated organisms were S. pneumoniae, H. influenzae, and S. aureus. Three-day azitromycin therapy was as effective as 10-day cefaclor therapy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. ISSN: 0165-5876
31- Erdamar, B; Keles, N; Kaur, A; Suoglu, Y; Kiyak, E Title: Expression of the cyclin-kinase inhibitors p21((WAF1)) and p27((Kip1)) and the p53 tumor suppressor genes in adult-onset laryngeal papillomas http://pcs.isiknowledge.com/uml/uml_view.cgi?product_sid=Z1eJGco...&print_opt=Field+Tagged&print_output.x=1&SID=Z1eJGco6ppb7kbOeP5b Page 6 of 9 Format for Print Page 3/28/11 11:59 AM Source: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 259 (10): 516-520 NOV 2002 Abstract: Different types of human papilloma virus are known to be closely associated with laryngeal papillomas. On the other hand, the proliferation of epithelial cells is associated with various abnormalities in the mechanisms of cellular regulation. In this study, we detected the expressions of p53, p21 and p27 proteins in adult-onset laryngeal papillomas by inummohistochemical techniques. The objective of this study is to evaluate the expression of these factors in adult-onset laryngeal papillomas and to determine whether such expression is correlated with the existence of dysplastic epithelium covering the papillomas. Eighteen patients with adult-onset papillomas who were surgically treated at the Department of Otolaryngology at the University of Istanbul between January 1994 and December 1999 were included in this study. Anti-p21, -p27 and -p53 antibodies were used to perform immunostaining. Positive nuclear staining for p2l was detected in 14 of the 18 (78%) cases, especially in the parabasal layer. Also, in 78% of the cases, weak to strong immunoreactivity was observed for p27. In all cases, negative immunoreactivity was observed for p53 throughout the epithelium except for the basal and parabasal cells. A negative correlation was observed between the existence of dysplastic epithelium and p21 expression (P=0.02). In conclusion, variable p21 and p27 expression was detected by immunohistochemistry in our series of 18 cases of adult-onset laryngeal papillomatosis, and a statistically significant inverse correlation was detected between p21 expression and the existence of dysplastic epithelium covering the papillomas. Further prospective studies are warranted to determine the prognostic values of these variables and to evaluate their role in the pathogenesis of adult-onset laryngeal papillomas. ISSN: 0937-4477 DOI: 10.1007/s00405-002-0502-x
32- Erdamar B, Süoğlu Y, Kiyak E, Güven M, Hafiz G, Aslan I, Metastasis to infraclavicular lymph nodes in head and neck cancer: a report of three cases., Kulak Burun Bogaz Ihtis Derg. 2002 Sep-Oct;9(5):368-71.PMID: 12471285 [PubMed - indexed for MEDLINE] ,
33- Erdamar B, Süoğlu Y, Kiyak E., [Current trends and future prospects in biological markers in squamous cell carcinoma of the head and neck] Kulak Burun Bogaz Ihtis Derg. 2002 Jul-Aug;9(4):301-3. Turkish. No abstract available. PMID: 12422088 [PubMed - indexed for MEDLINE]
34-Erdamar B, Süoğlu Y, Emin AH, Akdağ K, Kiyak E, Sunay T, Cölhan I., [Primary carcinoma of the subglottic larynx] Kulak Burun Bogaz Ihtis Derg. 2002 May-Jun;9(3):198-202. Turkish. PMID: 12415210 [PubMed - indexed for MEDLINE]
35- Suoglu, Y; Erdamar, B; Katircioglu, OS; Karatay, MC; Sunay, T Title: Extracapsular spread in ipsilateral neck and contralateral neck metastases in laryngeal cancer Source: ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 111 (5): 447-454 Part 1 MAY 2002 Abstract: We investigated the incidence of extracapsular spread (ECS) and the impact of ECS on contralateral neck metastasis in 67 patients with ipsilateral nodal metastasis (IpN+) whose records were extracted retrospectively from those of 155 laryngeal cancer patients. The incidence of ECS in association with variables was determined: T stage, N stage, tumor location, tumor extension, number of positive nodes, and contralateral neck status. The variables were evaluated to identify their impact on the rates of contralateral neck metastasis (CNM) and 3-year survival. Of the 67 patients, 30 (44.7%) had ECS. A significant relationship was found between ECS positivity and increased N stage, tumor extension up to the midline, number of positive nodes, and CNM (p=.04, p=.0001, p=.018. p=.0001, respectively). Multivariate analysis revealed that N stage (p=.002; odds ratio, 3.5517) and the presence of ECS (p=.0036; odds ratio, 7.7840) in IpN+ were associated with the greatest risk of CNM. The 3-year survival rate of patients with ipsilateral ECS was significantly lower than that of patients without ECS (43% versus 81%, p=.0002). Both CNM and presence of ECS in IpN+ emerged as significant independent predictors for survival with Cox multivariate analysis (p=.0086 and p=.0234, respectively). This result indicates the necessity of treating the contralateral NO neck in cases of IpN+ with ECS. ISSN: 0003-4894
36- Erdamar, B; Suoglu, Y; Cuhadaroglu, C; Katircioglu, S; Guven, M Title: Evaluation of clinical parameters in patients with obstructive sleep apnea and possible correlation with the severity of the disease Source: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 258 (9): 492-495 NOV 2001 Abstract: Obstructive sleep apnea (OSA) is a complex disease whose etiology is multifactorial and incompletely understood. This article focuses on upper airway anatomy evaluation and the standardization of different physical findings in patients with OSA and on the possible correlation of these physical findings with the severity of the disease. All patients underwent a physical examination and polysomnography. The physical examination included tonsil size, modified Mallampati grade, neck circumference, lateral clinical craniofacial assessment and body mass index (BMI). The study group consisted of 85 patients. A statistically significant correlation between tonsil size and BMI and with the respiratory disturbance index (RDI) was detected (P = 0.004 and 0.03 respectively). Also patients with a craniofacial anomaly have a higher RDI level than the patients without this anomaly (P = 0.03). This study has identified some standardized physical findings for predicting the severity of OSA. We aim to benefit from these http://pcs.isiknowledge.com/uml/uml_view.cgi?product_sid=Z1eJGco...&print_opt=Field+Tagged&print_output.x=1&SID=Z1eJGco6ppb7kbOeP5b Page 7 of 9 Format for Print Page 3/28/11 11:59 AM findings in the selection of a rational treatment modality selection for patients with OSA. ISSN: 0937-4477
37- Erdamar, B; Suoglu, Y; Sirin, M; Karatay, C; Katircioglu, S; Kiyak, E Title: Basaloid squamous cell carcinoma of the supraglottic larynx Source: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 257 (3): 154-157 MAR 2000 Abstract: Basaloid squamous cell carcinoma (BSC) is regarded as a variant of squamous cell carcinoma, but displays distinct morphological and biological features as well as a different clinical course. The tumor is frequently seen in the head and neck and is preferentially located in the larynx, especially in supraglottic sites. Ten patients with BSC of the supraglottic larynx were treated from 1991 to 1995 at the Medical Faculty of the University of Istanbul. Results of treatment were compared retrospectively with a control group consisting of 44 patients with well-differentiated squamous cell carcinomas. Ages, localizations, stages and treatment procedures were similar. In both groups mean survival, nodal involvement and distant metastases were comparable although the local (laryngeal) recurrence rate in patients with early supraglottic (T2) disease in the BSC group after conservative partial surgery was distinct compared to the control group (P < 0.05). These results indicate that conservative surgery should be assessed with caution in patients with BSC. and postoperative irradiation be taken into consideration. ISSN: 0937-4477
38- Unal, M; Katircioglu, S; Karatay, MC; Suoglu, Y; Erdamar, B; Aslan, I Title: Sudden total bilateral deafness due to asymptomatic mumps infection Source: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 45 (2): 167-169 OCT 2 1998 Abstract: Mumps is the most common cause of unilateral acquired sensorineural hearing loss in children. Although it usually affects the salivary glands, the inner ear may be involved. Deafness is usually unilateral, sudden in onset, profound and permanent. Bilateral total sensorineural hearing loss had been rarely reported in English literature. We present a case of total deafness due to asymptomatic mumps infection. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. ISSN: 0165-5876
39- Suoglu, Y; Erdamar, B; Colhan, I; Katircioglu, OS; Cevikbas, U Title: Tuberculosis of the parotid gland Source: JOURNAL OF LARYNGOLOGY AND OTOLOGY, 112 (6): 588-591 JUN 1998 Abstract: The presentation of tuberculosis as an isolated parotid lump is rare. In this paper, six cases with tuberculous parotitis are reported which were evaluated as a benign parotid neoplasm in 216 specimens pre-operatively. All but one of them had no previous history of tuberculosis and all had a parotid lump as a sole symptom for at least one year. The diagnosis of tuberculosis was made, after superficial parotidectomy, by histopathology. Parenchymal involvement and intraparotid lymph node involvement with tuberculosis were seen in five and three patients, respectively. Two of the patients had lymph node involvement outside the parotid area. One of six patients had a coincidental Warthin tumour. A surgical approach is not only therapeutic but also diagnostic when other diagnostic tools fail. ISSN: 0022-2151
40- KATIRCIOGLU, S; KATIRCIOGLU, OS; SUNAY, T; KARATAY, MC; SARACAYDIN, A; SUOGLU, Y; TOPUZ, B Editor(s): Sunar, O; Altug, T; Devranoglu, I Title: AZATHIOPRINE COMBINED WITH CORTICOSTEROID THERAPY IN SUDDEN HEARING LOSS Source: ISTANBUL'93 - XV. WORLD CONGRESS OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, PROCEEDINGS, VOLS 1-3: 276-279 1993 Conference Title: XV World Congress of Otorhinolaryngology Head and Neck Surgery (ISTANBUL 93) Conference Date: JUN 20-25, 1993 Conference Location: ISTANBUL, TURKEY ISBN: 0-906522-07-2
41- KARATAY, MC; COLHAN, MD; SARACAYDIN, A; KATIRCIOGLU, S; SUOGLU, Y; OZTURK, AS Editor(s): Sunar, O; Altug, T; Devranoglu, I Title: OLFACTORY NEUROBLASTOMA - LIGHT MICROSCOPIC AND ULTRASTRUCTURAL FINDINGS IN ONE CASE Source: ISTANBUL'93 - XV. WORLD CONGRESS OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, PROCEEDINGS, VOLS 1-3: 608-611 1993 Conference Title: XV World Congress of Otorhinolaryngology Head and Neck Surgery (ISTANBUL 93) Conference Date: JUN 20-25, 1993 Conference Location: ISTANBUL, TURKEY ISBN: 0-906522-07-2
42- KARATAY, MC; KATIRCIOGLU, S; SUOGLU, Y; SARACAYDIN, A; TUZLALI, P; OZTURK, S Editor(s): Sunar, O; Altug, T; Devranoglu, I Title: CARCINOID TUMOR OF THE LARYNX REPORT OF A CASE Source: ISTANBUL'93 - XV. WORLD CONGRESS OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, PROCEEDINGS, VOLS 1-3: 774-777 1993 Conference Title: XV World Congress of Otorhinolaryngology Head and Neck Surgery (ISTANBUL 93) Conference Date: JUN 20-25, 1993 Conference Location: ISTANBUL, TURKEY ISBN: 0-906522-07-2
43- SUNAY, T; SARACAYDIN, A; KARATAY, MC; KATIRCIOGLU, S; SUOGLU, Y Editor(s): Sunar, O; Altug, T; Devranoglu, I Title: CHONDROMA OF THE LARYNX Source: ISTANBUL'93 - XV. WORLD CONGRESS OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, PROCEEDINGS, VOLS 1-3: 782-785 1993 Conference Title: XV World Congress of Otorhinolaryngology Head and Neck Surgery (ISTANBUL 93) Conference Date: JUN 20-25, 1993 Conference Location: ISTANBUL, TURKEY ISBN: 0-906522-07-2